The value of T2 signal intensity in DTI to differentiate between brain tumor infiltration and pure vasogenic edema / 实用放射学杂志

Objective To explore the added value of T2-signal intensity (T2-SI) in discriminating tumor-infiltration from pure vasogenic edema with diffusion tensor imaging (DTI).Methods 55 patients with brain tumors [28 with high-grade glioma (HGG),13 with meningioma,and 14 with metastases] and concurrent peritumoral edema were scanned with DTI.The mean fractional anisotropy (FA),mean diffusivity (MD),longitudinal diffusivity (λ//) and radial diffusivity (λ⊥) in peritumoral edema of different tumors were measured and compared with each other.Results Only the mean FA showed significant difference between edema of HGG and meningioma (P＜0.05).When standardized T2-SI was used as the covariant,FA and λ⊥ showed significant differences among the tumor groups.The adjusted FA in edema of HGG was significantly lower than that of metastases (P＜0.05) and meningioma (P＜ 0.001).The adjusted λ⊥ in edema of HGG was significantly higher than that of meningioma (P＜0.05).Conclusion By controlling the effect of T2-SI,the value of DTI in distinguishing tumor-infiltration from pure vasogenic edema could be improved.

Accuracy of dual-energy CT in diagnosing gouty arthritis:a Meta-analysis / 实用放射学杂志

Objective To estimate the diagnostic value of dual-energy CT in gouty arthritis.Methods English and Chinese litera-tures publicated before May 2014 were searched in PubMed,Embase,Cochrane and Wanfang database.Available literatures were selected according to the inclusion and exclusion criterias.Sensitivity,specificity with 95% confidence interval (95% CI)was pooled with bivariate random-effects model.Hierarchical weighted symmetric summary receiver-operating curve (HSROC)was also used in estimating.Meta-regression and sensitivity analysis were used to explore the potential sources of heterogeneity.Results Nine studies were included in the analysis.The pooled sensitivity,specificity and 95% CI were 92%(84-96%)and 88%(83-92%)respectively, area under the HSROC curve was 0.91 (0.88-0.93).There was substantial heterogeneity between studies(I 2 =85%).Conclusion Dual-energy CT is accuracy in diagnosing gouty arthritis.The sources of heterogeneity was not been explored.

Transforming growth factor β1 enhances the invasiveness of human glioma cell line via ERK/MAPK pathway / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate the effect of transforming growth factor β1 (TGF-β1) on the invasiveness of human glioma SF767 cell line in vitro and explore the possible molecular mechanism.</p><p><b>METHODS</b>Human glioma SF767 cell line treated with TGF-β1 for 12, 24, or 48 h were examined for the expressions of epithelial-mesenchymal transition- and ERK/MAPK pathway-associated proteins using Western blotting. MTT assay and Transwell assay were employed to assess the changes in the cell proliferation and invasiveness after TGF-β1 treatment, respectively.</p><p><b>RESULTS</b>Western blotting showed that TGF-β1 treatment up-regulated the expressions of vimentin, MMP-2, P-ERK, and Zeb-1 and down-regulated E-cadherin expression in SF767 cells. TGF-β1 treatment of the cells resulted in significantly shortened doubling time of cells and obviously increased cell invasiveness.</p><p><b>CONCLUSION</b>TGF-β1 induces epithelial-mesenchymal transition of SF767 cell line to increase its invasiveness possibly via ERK/MAPK pathway.</p>

Analysis on the relationship between tensor veli palatini and secretory otitis media in patients with nasopharyngeal carcinoma after radiotherapy / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#The analyze the relationship between secretory otitis media (SOM) and injury of tensor veli palatini (TVP) muscle injury after radiotherapy, then to explore the pathogenesis of SOM in patients with nasopharyngeal carcinoma (NPC) after radiotherapy.@*METHOD@#The cross section area (CSA) of TVP and medial pterygoid (MP) muscle were measured in MRI of 32 patients with NPC before and after radiotherapy, meanwhile the incidence of SOM were surveyed after radiotherapy, then to analyze the relationship between the change of TVP and the incidence of SOM after radiotherapy.@*RESULT@#Of 48 ears without SOM before radiotherapy, 27 ears developed post-irradiation SOM, including 24 ears with TVP atrophy and 3 ears without TVP atrophy, and 21 ears had no post-irradiation SOM, including 8 ears with TVP atrophy and 13 ears without TVP atrophy. chi2 test showed significant difference (P < 0.01). It indicated that post-irradiation SOM have correlation with TVP atrophy. The more possibility of TVP atrophy occurred after long time radiotherapy.@*CONCLUSION@#The atrophy of TVP in patients with NPC usually occurs 6 months after radiotherapy, and this may result in the post-irradiation SOM. The pathogenesis of post-irradiation SOM need further study functionally.

Laparoscopic versus Open Cholecystectomy in Aged Patients in Plateau Region:A Clinical Comparison of Cardiopulmonary Complications / 中国微创外科杂志

Objective To evaluate the safety of laparoscopic cholecystectomy's in aged patients in plateau region.Method From January 2005 to June 2006,a total of 64 local aged gallbladder disease patients were included,in which 32 cases received open cholecystectomy(OC)and 32 cases received laparoscopic cholecystectomy(LC).Postoperative cardiopulmonary complications were compared.Results In the LC group,1 case of acute pneumonedema,1 case of chronic right heart failure and 1 case of pulmonary infection occurred;and 3 cases of left heart failure accompanied with pneumonedema,2 cases of right heart failure and 5 cases of pulmonary infection occurred in the OC group.The incidence of cardiopulmonary complications of the LC group was significantly lower than that of the OC group(9% vs 31%,?2=4.730,P=0.030).Conclusions In the circumstances of high altitude,low atmospheric pressure and low oxygen partial pressure,LC is safer than OC for aged patients in regard to postoperative complications.